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2026
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Integrative genomics elucidates the evolutionary, temporal, and developmental origins of a hydrocephalus risk gene.
Experimental Neurology. 2026 Jul;401:115725. Epub 2026 Mar 12.
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Comprehensive characterization of V(D)J recombination from long-read transcriptomic data with VDJcraft.
bioRxiv. 2026 Apr 5. Preprint.
Abstract -
Bmal1 Regulates Vascular Calcification via Noncanonical Circadian Pathway—Brief Report.
Arteriosclerosis, Thrombosis, and Vascular Biology. 2026 Apr;46(4):e324061. Epub 2026 Jan 29.
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Exosomes Transfer ST6GAL1-mediated Therapeutic Resistance in Rectal Cancer Cells.
Cancer Genomics & Proteomics. 2026 Jan-Feb;23(1):12-26.
Abstract
2025
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Molecular predictors of treatment resistance and recurrence following neoadjuvant therapy in rectal cancer.
BMC Cancer. 2025 Oct 22;25(1):1624.
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Circadian Factor Bmal1 Regulates Vascular Calcification.
American Journal of Pathology. 2025 Apr 1;195(4).
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A detailed guide to assessing genome assembly based on long-read sequencing data using Inspector.
Nat Protoc. 2025 Mar 26. Epub ahead of print.
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Age- and ApoE Genotype-Dependent Transcriptomic Responses to O3 in the Hippocampus of Mice.
Int J Mol Sci. 2025 Mar 7;26(6):2407.
Abstract
2024
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Smooth Muscle Cells – Expressed Bmal I Regulates Vascular Calcification Independent of the Canonical Circadian Pathway.
bioRxiv. 2024 Jul 22.
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Endoluminal Biopsy for Vein of Galen Malformation.
Neurosurgery. 2024 Nov 1;95(5):1082-1088. Epub 2024 May 15.
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The genetic basis of hydrocephalus: genes, pathways, mechanisms, and global impact.
Fluids Barriers CNS. 2024 Mar 4;21(1):24.
Abstract -
Body Weight Correlates with Molecular Variances in Patients with Cancer.
Cancer Res. 2024 Mar 4;84(5):757-770.
Abstract
2023
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Novornabreak: Local Assembly for Novel Splice Junction and Fusion Transcript Detection from RNA-Seq Data.
J Bioinform Syst Biol. 2023 Apr 4;6(2):74-81.
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Deciphering the exact breakpoints of structural variations using long sequencing reads with DeBreak.
Nat Commun. 2023 Jan 17;14(1):283.
Abstract
2022
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Gene fusion detection and characterization in long-read cancer transcriptome sequencing data with FusionSeeker.
Cancer Res. 2022 Nov 1:CAN-22-1628. Epub ahead of print.
Abstract -
Protein arginine methyltransferase 1 in the generation of immune megakaryocytes: A perspective review.
J Biol Chem. 2022 Sep 21;298(11):102517. Epub ahead of print.
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High-coverage whole-genome sequencing of the expanded 1000 Genomes Project cohort including 602 trios.
Cell. 2022 Sep 1;185(18):3426-3440.e19.
Abstract -
Selective suppression of melanoma lacking IFN-γ pathway by JAK inhibition depends on T cells and host TNF signaling.
Nat Commun. 2022 Aug 25;13(1):5013.
Abstract -
Reduced sister chromatid cohesion acts as a tumor penetrance modifier.
PLoS Genet. 2022 Aug 22;18(8):e1010341.
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B-assembler: a circular bacterial genome assembler.
BMC Genomics. 2022;23:361.
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Protein arginine methyltransferase 1 in the generation of immune megakaryocytes: A perspective review.
J Biol Chem. 2022 Sep 21;298(11):102517.
Abstract
2021
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Accurate long-read de novo assembly evaluation with Inspector.
Genome Biol. 2021 Nov 14;22(1):312.
Abstract -
RNF2 ablation reprograms the tumor-immune microenvironment and stimulates durable NK and CD4+ T-cell-dependent antitumor immunity.
Nat Cancer. 2021;2:1018–1038.
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Haplotype-resolved diverse human genomes and integrated analysis of structural variation.
Science. 2021 Feb 25:eabf7117.
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ClipSV: improving structural variation detection by read extension, spliced alignment and tree-based decision rules.
NAR Genom Bioinform. 2021 Feb 1;3(1):lqab003.
Abstract
2020
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Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples.
Nat Commun. 2020 Sep 21;11(1):4748.
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Sex differences in oncogenic mutational processes.
Nat Commun. 2020 Aug 28;11(1):4330.
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Ozone and Particulate Matter Exposure and Alzheimer's Disease: A Review of Human and Animal Studies.
J Alzheimers Dis. 2020;76(3):807-824.
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Pan-cancer analysis of whole genomes.
Nature. 2020 Feb;578(7793):82-93.
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Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition.
Nat Genet. 2020 Mar;52(3):306–319.
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The effects of common structural variants on 3D chromatin structure.
BMC Genomics. 2020 Jan 30;21(1):95.
Abstract -
De novo mutations across 1,465 diverse genomes reveal mutational insights and reductions in the Amish founder population.
Proc Natl Acad Sci U S A. 2020 Feb 4;117(5):2560-2569. Epub 2020 Jan 21.
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MRLR: unraveling high-resolution meiotic recombination by linked reads.
Bioinformatics. 2020 Jan 1;36(1):10-16.
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Ozone and Particulate Matter Exposure and Alzheimer's Disease: A Review of Human and Animal Studies.
J Alzheimers Dis. 2020;76(3):807-824.
Abstract
2019
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Human-specific tandem repeat expansion and differential gene expression during primate evolution.
Proc Natl Acad Sci U S A. 2019 Nov 12;116(46):23243-23253.
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Scalable De Novo Genome Assembly Using a Pregel-Like Graph-Parallel System.
IEEE/ACM Trans Comput Biol Bioinform. 2019 Jun 5.
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Multi-platform discovery of haplotype-resolved human genomes.
Nature Communications. 2019 Apr 16.
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Megabase Length Hypermutation Accompanies Human Structural Variation at 17p11.2.
Cell. 2019 Mar 7;176(6):1310-1324.e10.
Abstract
2018
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Combining accurate tumor genome simulation with crowdsourcing to benchmark somatic structural variant detection.
Genome Biol. 2018 Nov 6;19(1):188.
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Regenerative Potential of Neonatal Porcine Hearts.
Circulation. 2018 Dec 11;138(24):2809-2816.
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In vivo screening identifies GATAD2B as a metastasis driver in KRAS-driven lung cancer.
Nat Commun. 2018 Jul 16;9(1):2732.
Abstract -
Marker chromosome genomic structure and temporal origin implicate a chromoanasynthesis event in a family with pleiotropic psychiatric phenotypes.
Hum Mutat. 2018 Jul;39(7):939-946.
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Structural Variant Breakpoint Detection with novoBreak.
Methods Mol Biol. 2018;1833:129-141.
Abstract
2017
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A Community Challenge for Inferring Genetic Predictors of Gene Essentialities through Analysis of a Functional Screen of Cancer Cell Lines.
Cell Syst. 2017 Nov 22;5(5):485-497.e3.
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A murine preclinical syngeneic transplantation model for breast cancer precision medicine.
Sci Adv. 2017 Apr 19;3(4):e1600957.
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An Organismal CNV Mutator Phenotype Restricted to Early Human Development.
Cell. 2017 Feb 23;168(5):830-842.e7.
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Integrated genomic and molecular characterization of cervical cancer.
Nature. 2017 Jan 23.
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novoBreak: local assembly for breakpoint detection in cancer genomes.
Nat Methods. 2017 Jan;14(1):65-67.
Abstract
2016
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Single-cell isolation by a modular single-cell pipette for RNA-sequencing.
Lab Chip. 2016 Nov 29;16(24):4742-4748.
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Hotspot mutations delineating diverse mutational signatures and biological utilities across cancer types.
BMC Genomics. 2016 Jun 23;17 Suppl 2:394.
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Functional annotation of rare gene aberration drivers of pancreatic cancer.
Nat Commun. 2016 Jan 25;7:10500.
Abstract
2015
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Identification of Variant-Specific Functions of PIK3CA by Rapid Phenotyping of Rare Mutations.
Cancer Res. 2015 Dec 15;75(24):5341-54.
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TransVar: a multilevel variant annotator for precision genomics.
Nat Methods. 2015 Nov;12(11):1002-3.
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An integrated map of structural variation in 2,504 human genomes.
Nature. 2015 Oct 1;526(7571):75-81.
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A global reference for human genetic variation.
Nature. 2015 Oct 1;526(7571):68-74.
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ClinSeK: a targeted variant characterization framework for clinical sequencing.
Genome Med. 2015 Mar 31;7(1):34.
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Genome-wide 5-hydroxymethylcytosine modification pattern is a novel epigenetic feature of globozoospermia.
Oncotarget. 2015 Mar 30;6(9):6535-43.
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Clinical actionability enhanced through deep targeted sequencing of solid tumors.
Clin Chem. 2015 Mar;61(3):544-53.
Abstract
2014
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Towards accurate characterization of clonal heterogeneity based on structural variation.
BMC Bioinformatics. 2014 Sep 8;15:299.
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Trrap-dependent histone acetylation specifically regulates cell-cycle gene transcription to control neural progenitor fate decisions.
Cell Stem Cell. 2014 May 1;14(5):632-43.
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Ago2 facilitates Rad51 recruitment and DNA double-strand break repair by homologous recombination.
Cell Res. 2014 May;24(5):532-41.
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Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism.
Nucleic Acids Res. 2014 Feb;42(3):1593-605.
Abstract
2013
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Pseudo-Sanger sequencing: massively parallel production of long and near error-free reads using NGS technology.
BMC Genomics. 2013 Oct 17;14:711.
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The evolution of small insertions and deletions in the coding genes of Drosophila melanogaster.
Mol Biol Evol. 2013 Dec;30(12):2699-708.
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Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals.
J Am Chem Soc. 2013 Jul 17;135(28):10396-403.
Abstract
2012
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Rainbow: an integrated tool for efficient clustering and assembling RAD-seq reads.
Bioinformatics. 2012 Nov 1;28(21):2732-7.
Abstract
2011
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Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data.
Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12042-7.
Abstract